Single Particle ICP-MS (SP-ICP-MS) a New Analytical Technique for Counting and Sizing Metal Based Nanomaterials: Theory and Application

C. Stephan
PerkinElmer, CA

Keywords: single particle ICP-MS, counting, sizing, metal based nanomaterials


Engineered Nanomaterials (ENMs) often possess different properties than bulk materials of the same composition, making them of great interest to a broad spectrum of industrial and commercial applications. The widespread use and application of ENMs will inevitably lead to their release into the environment, which raises concern about their potential adverse effects on the ecosystems and, subsequently, human health. To better understand ENMs in the environment, the following ENM characteristics will aid in this assessment: concentration, composition, particle size, shape, and other surface characteristics. This work describes the use of Single Particle- ICP-MS in analyzing Metal Based Nanoparticles. Single Particle (SP-ICP-MS) allow the differentiation between ionic and particulate signals, quantitate both the ionic and particulate fraction, measures particle concentration (part/mL), particle sizes (if shape is known), and explores agglomeration and size distribution. SP-ICP-MS is a key analytical instrument in assessing the fate, behavior and distribution of (ENMs) in several types of matrices (environment, food, etc.), evaluating ENMs bioavailability and bioaccumulation in the biota, and improving bio-labeling capabilities and advancements in the medical field.