Magnetic Targeting of Human Aortic Smooth Muscle Cells for Rapid Closure and Healing of Intracranial Aneurysm/Pseudoaneurysm

S.L. Arias, M. Alucozai, F. Pastrana, L.M. Reece, R. Kempaiaih, J.J. Pavon, J.P. Allain
Purdue University, US

Keywords: aneurysm, vascular repair, smooth muscle cells, magnetic labeling

Summary:

A novel approach is proposed in this study using a magnetic strategy to address the current disadvantages of detachable coils and stent grafts for aneurysm/pseudoaneurysm treatment. It consists of a patch facing the aneurysm neck defect capable of reducing the flow inside it and bridging the aneurysm neck. The patch is thought to have the ability to attract locally magnetized smooth muscle cells and promote the wound healing through rapid cell migration, adhesion, proliferation and deposition of the extracellular matrix, which are essential requisites for vessel integrity and vascular repair. To test the feasibility of this approach, we have enhanced the cellular uptake of nanoparticles via electroporation for magnetic cell delivery, so that improved cell guidance and retention on the patch will be conferred for rapid favorable healing of the aneurysm neck.