Multifunctional squalenoyl nanocomposites for pancreatic cancer: diagnostic and therapeutic aspects

S. Valetti, B. Stella, S. Mura, D. Desmaële, F. Maione, E. Giraudo, L. Cattel, P. Couvreur
University of Paris, FR

Keywords: nanoparticles, active targeting, pancreatic cancer, theranostics

Summary:

The “squalenoylation” nanotechnology consists in the linkage of squalene, a natural and well tolerated triterpene, to anticancer drugs and antiviral nucleoside analougues. This stategy, which allows to achieve a high drug loading together with a high therapeutic efficiency and the possibility to overcome the resistance to current available treatments, represents a new and original approach for delivering therapeutic compounds. The aim of this project is to design a novel theranostic multifunctional nanomedicine which combines both tumor targeting and imaging functionalities. Multifuctional nanoparticles were prepared by the self-assemblage in water of squalene-based prodrugs and their surface was decorated with specific ligands able to selectively target pancreatic cancer cells. Imaging properties and cancer therapeutic activity will be obtained via the encapsulation of iron oxide nanoparticles.Preliminary results make these multifunctional nanoparticles extremely appealing for application in pancreatic cancer management.