Study on the polymeric nanosphere with imaging functionality

M-H Lin, T-Y Liu
Institute of Biomedical Engineering, National Yang-Ming University, Taipei, 112 Taiwan (ROC), TW

Keywords: contrast function, drug carriers, drug delivery systems (DDSs), magnetic resonance (MR), fluorescence


The aim of this research was to develop a novel contrast agent with magnetic resonance (MR) imaging, fluorescent imaging and drug encapsulation functionalities. The zinc oxide (ZnO) nanoparticles and superparamagnetic iron oxide (Fe3O4) nanoparticleswas prepared by thermal decomposition method.The amphiphilic chitosan derivative (ACD) was conjugated with folic acid (FA) molecules. Fe3O4 and ZnO suspensions were added to ACD solution and sonicated with a probe-type sonicator at the interface for few minutes. Subsequently, the ACD-based nanospheres containing ZnO and Fe3O4 nanoparticles (AZF nanosphere) were prepared. We successfully fabricated a novel folic acid-conjugated drug vehicle to demonstrate dual modal imaging functionality (fluorescence and MR imaging) and encapsulate hydrophobic drug. Hence, FA-AZF nanospheres could be assessed as an anti-cancer drug delivery vehicle to specifically target the folic acid receptor overexpressing tumor cells.