Cancer Nanotechnology

Symposium Co-Chairs
Translational Cancer Nano-Medicine: Multimodal Strategies to Overcome Tumor Drug Resistance Mansoor M. Amiji Distinguished Professor and Chairman Department of Pharmaceutical Sciences Co-Director, Nanomedicine Education and Research Consortium (NERC) , Northeastern University, Boston MA	Vladimir Torchilin Distinguished Professor of Pharmaceutical Sciences Director Center for Pharmaceutical Biotechnology and Nanomedicine Bouvé College of Health Sciences
Confirmed Invited Speakers
Nano-Therapeutics for Blocking Multiple Targets: New Age for Combination Cancer Treatments Julia Y. Ljubimova Professor of Neurosurgery and Biomedical Sciences & Director of Nanomedicine Research Center, , Cedars-Sinai Medical Center	Vascular and tumor imaging using targeted viral nanoparticles Marianne Manchester Professor, University of California at San Diego
Image-guided cancer therapy using theranostic nanoparticles Lily Yang Associate Professor, Emory University School of Medicine	Therapeutic gene silencing in vivo using RNA interference Anil K. Sood Professor, M.D. Anderson Cancer Center
Fluid Biopsy in Solid Tumors, how HD-CTCs can provide real-time insights into cancer Peter Kuhn Director and Principal Investigator; Associate Professor, Scripps Physics Oncology Center; The Scripps Research Institute	Top Down Nanotechnology for Cancer Diagnostics Rashid Bashir Abel Bliss Professor of Engineering, University of Illinois
Nanoscience Strategies for the Design and Ultra Sensitive Readout of Dense Immunodiagnostic Platforms Marc Porter Director, Nano Institute of Utah; USTAR Professor, Departments of Analytical Chemistry, Chemical Engineering, Bioengineering, and Pathology, University of Utah	Demir Akin Deputy Director, Center for Cancer Nanotechnology Excellence, School of Medicine Stanford University
Cell-Nanomaterial Interaction: Implications in Cell-Signaling and Targeted Therapy Rachel Kudgus Research Fellow, Mayo Clinic	Top Down Nanotechnology for Cancer Diagnostics Rashid Bashir Abel Bliss Professor of Engineering, University of Illinois

Symposium Sessions
	Tuesday June 19
12:30	Networking Lunch - Expo
2:45	TechConnect IP Partnering: Medical, Pharma, Personal Care
4:00	Financing Emerging Technology Commercialization, Greenberg Traurig
4:30	Expo Reception and Poster Session I
	Cancer Nanotechnology
	Wednesday June 20
8:30	Cancer Nanotech I
10:30	Cancer Nanotech II
12:30	Networking Lunch - Expo
1:00	NNI - Director's Networking Session, National Nanotechnology Coordination Office
1:30	Exhibit and Poster Session II
	Cancer Nanotechnology
3:30	Cancer Nanotech III
5:30	TechConnect Innovation Showcase Reception
6:00	CTSI Utility Technology Challenge Awarde and Reception
	Thursday June 21
8:30	Cancer Nanotech IV
10:00	National Nanotechnology Initiative Triennial Review
12:30	Networking Lunch - Innovation Showcase
2:30	TechConnect Start-Up Partnering: Medical, Pharma, Personal Care
4:00	TechConnect Start-Up Partnering: Biotech, Biomaterials & Biosciences
4:00	TechConnect National Innovation Showcase, Reception & Poster Session III
Symposium Program
	Tuesday June 19
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12:30	Networking Lunch - Expo	Expo Hall AB
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2:45	TechConnect IP Partnering: Medical, Pharma, Personal Care	Room 207
	Session chair: Belen Martinez-Lopez, CaramelTech, MX
2:45	NCap - NanoPorous Materials for Sustained Release W. Daniell, NanoScape AG, DE
2:55	Medical Nano-magnetic Drug Guidance A. Harel, NanoMed Targeting Systems Inc., US
3:05	Universal Optofluidic Chip for Ultra-Sensitive Raman Analysis of Liquid S. Mak, University of Toronto, CA
3:15	Next generation single dose vaccine adjuvants S. Niewiesk, The Ohio State University, US
3:25	Double Clad Fiber Coupler Allowing 3D Endoscopy T. Martinuzzo, Univalor, CA
3:35	Nanogold Assays for Direct Detection of Nucleic Acids of High Burden Infections H. Azzazy, The American University in Cairo, EG
3:45	A Liquid Crystal Polymer (LCP) Membrane MEMS Sensor for Flow Rate and Flow Direction Sensing, Medical and Environmental Applications L.M. Sim, Industry Liaison Office, National University of Singapore (NUS), SG
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4:00	Financing Emerging Technology Commercialization, Greenberg Traurig	Room 203
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4:30	Expo Reception and Poster Session I	Expo Hall AB
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	Cancer Nanotechnology
-	Immunodiagnosis for cervical cancer using antibody-gold nanoparticle conjugate S. Tapaneeyakorn, C. Thepthai, N. Apiwat, T. Dharakul, National Science and Technology Development Agency, TH
-	Dual gold nanoparticles-enhanced sensitivity of colorimetric immunoassay for the visual detection of cervical cancer biomarker W. Maneeprakorn, N. Apiwat, S. Tapaneeyakorn, T. Dharakul, National Nanotechnology Center, National Science and Technology Development Agency, TH
-	Activation of Inflammasomes by Tumor Cell Death Mediated by Gold Nanoshells H.T. Nguyen, K.K. Tran, B. Sun, H. Shen, University of Washington, US
-	Targeted Cancer Therapy by Immunoconjugated Gold-Gold Sulfide Nanoparticles Using Protein-G as a Cofactor X.H. Sun, G.D. Zhang, D. Patel, A.M. Gobin, University of Louisville, US
-	Supermagnatic Iron Oxide Nanoparticles Toxicity to Mammalian Cells K. Vig, P. Tiwari, A. Parveen, V. Rangari, S.R. Singh, Alabama State University, US
	Wednesday June 20
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8:30	Cancer Nanotech I	Grand Ballroom A
	Session chair: Mansoor Amiji, Northeastern University, US
8:30	Top Down Nanotechnology for Cancer Diagnostics R. Bashir, University of Illinois, US
9:15	Nanoscience Strategies for the Design and Ultra Sensitive Readout of Dense Immunodiagnostic Platforms M. Porter, University of Utah, US
9:45	Fluid Biopsy in Solid Tumors, how HD-CTCs can provide real-time insights into cancer P. Kuhn, Scripps Physics Oncology Center; The Scripps Research Institute, US
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10:30	Cancer Nanotech II	Grand Ballroom A
	Session chair: Mansoor Amiji, Northeastern University, US
10:30	Nanomedicine for early detection of cancer and cancer therapy response monitoring D. Akin, Stanford University, US
11:00	Cell-Nanomaterial Interaction: Implications in Cell-Signaling and Targeted Therapy R. Kudgus, Mayo Clinic, US
11:30	Therapeutic gene silencing in vivo using RNA interference A. Sood, M.D. Anderson Cancer Center, US
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12:30	Networking Lunch - Expo	Exhibit Hall AB
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1:00	NNI - Director's Networking Session, National Nanotechnology Coordination Office	Exhibit Hall A
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1:30	Exhibit and Poster Session II	Exhibit Hall AB
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	Cancer Nanotechnology
-	Mn-Zn Ferrite and Photosensitizer Co-Loaded Cancer Theranostic Agent for Magnetic Resonance Imaging and Photodynamic Therapy S.-M. Lai, M.-D. Yang, M.-J. Tung, P.-S. Lai, National Chung Hsing University, TW
-	Copper complexes loaded on nanostructured TiO2 materials as citotoxic agents of cancer cells T. Lopez, E. Ortiz, P. Guevara, E. Gómez, Instituto Nacional de Neurologia y Neurocirugia, MX
-	Electrospun 5-fluorouracil loaded bovine serum albumin-polyvinylpyrrolidone nanofibers U.E. Illangakoon, N.P. Chatterton, G.R. Williams, T. Nazir, London Metropolitan University, UK
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3:30	Cancer Nanotech III	Grand Ballroom A
	Session chair: Mansoor Amiji, Northeastern University, US
3:30	Nano-Therapeutics for Blocking Multiple Targets: New Age for Combination Cancer Treatments J. Ljubimova, Cedars-Sinai Medical Center, US
4:00	Vascular and tumor imaging using targeted viral nanoparticles M. Manchester, University of California, San Diego, US
4:30	Systemic Responses to Targeted Nanoparticle Imaging and Theranostic Agents L. Yang, Emory University School of Medicine, US
5:00	Translational Cancer Nano-Medicine: Multimodal Strategies to Overcome Tumor Drug Resistance M. Amiji, Northeastern University, US
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5:30	TechConnect Innovation Showcase Reception	Expo Hall CD
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6:00	CTSI Utility Technology Challenge Awarde and Reception	Expo Theater 1
	Session chair: Patti Glaza, Arsenal Venture Partners, US
	Thursday June 21
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8:30	Cancer Nanotech IV	Grand Ballroom A
	Session chair: Mansoor Amiji, Northeastern University, US
8:30	Polymalic acid-based nanodrugs: Anti-tumor efficacy and host compatibility E. Holler, Hui Ding, R. Patil, J. Portilla, S. Inoue, P. Gangulum, S.E. McNeil, A. Patri, M.A. Dobrovolskaia, K.L. Black, J.Y. Ljubimova, Cedars-Sinai Medical Center, US
8:50	EGF conjugated gold and silver nanoparticles for imaging EGFR over-expressing cells L.J. Lucas, K.C. Hewitt, Dalhousie University, CA
9:10	Efficient “green” technology to load an anticancer drug, gemcitabine monophosphate, into Iron-Trimesate MOF nanoparticles V.R. Ruiz, V. Agostoni, H. Willaime, P. Horcajada, C. Serre, M. Lampropoulou, K. Yanakopoulous, R. Gref, Université Paris-Sud, FR
9:30	VEGF-dependent mechanism of anti-angiogenic action of diamond nanoparticles in glioblastoma multiforme tumor. M. Grodzik, E. Sawosz, M. Wierzbicki, A. Hotowy, M. Prasek, S. Jaworski, A. Chwalibog, Warsaw University of Life Sciences, PL
9:50	Combined targeted hyperthermia and drug delivery with magnetic nanoparticles T. Mitrelias, M. Tselepi, C. Barnes, V. Orel, I. Schepotin, Cavendish NanoTherapeutics, UK
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10:00	National Nanotechnology Initiative Triennial Review	Great America 1
	Session chair: Erik Svedberg, National Materials and Manufacturing, National Academies, US
10:00	NNI Town Hall Meeting TBD, National Nanotechnology Initiative, US
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12:30	Networking Lunch - Innovation Showcase	Expo Hall CD
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2:30	TechConnect Start-Up Partnering: Medical, Pharma, Personal Care	Expo Theater 2
	Session chair: Paul Prendergast, Merchant & Gould, US
2:30	IntuitiveMediCorp J.U. Kim, IntuitiveMediCorp, KR
2:40	Nano-Magnetic drug targeting A. Harel, NanoMed Targeting Systems Inc., US
2:50	Leukocyte coping capacity: stress-testing at your fingertips D. Sarphie, Oxford MediStress Ltd, US
3:00	Reagent-free nanobiomimetic electrochemical sensing platform E. Chen, Advanced Biomimetic Sensors, Inc., US
3:10	Magnetic nanotechnology for targeted cancer treatment T. Mitrelias, Cavendish NanoTherapeutics, UK
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4:00	TechConnect Start-Up Partnering: Biotech, Biomaterials & Biosciences	Expo Theater 2
	Session chair: Paul Prendergast, Merchant & Gould, US
4:00	Laser Transmission Spectroscopy C. Tanner, LightSprite, LLC, US
4:10	Novel Shape Memory foam devices for neurovascular and other vascular applications D. Maitland, Shape Memory Therapeutics, US
4:20	Biologue Continuous Glucose Monitoring System J. Willis, Ultradian Diagnostics LLC, US
4:30	Mobile Biosensors for Early Disease Detection V. Novotny, AltraSense Inc., US
4:40	Lux World Co., Ltd. S. Kang, Lux World Co., Ltd., KR
4:50	Disruptive wireless silicon platform for disposable wireless healthcare sensors S. Magar, HMicro, Inc., US
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4:00	TechConnect National Innovation Showcase, Reception & Poster Session III	Expo Hall CD

Special Symposium

Nanotechnology has the potential to have a revolutionary impact on cancer diagnosis and therapy. It is universally accepted that early detection of cancer is essential even before anatomic anomalies are visible. A major challenge in cancer diagnosis in the 21st century is to be able to determine the exact relationship between cancer biomarkers and the clinical pathology, as well as, to be able to non-invasively detect tumors at an early stage for maximum therapeutic benefit. For breast cancer, for instance, the goal of molecular imaging is to be able to accurately diagnose when the tumor mass has approximately 100-1000 cells, as opposed to the current techniques like mammography, which require more than a million cells for accurate clinical diagnosis.

In cancer therapy, targeting and localized delivery are the key challenges. To wage an effective war against cancer, we have to have the ability to selectively attack the cancer cells, while saving the normal tissue from excessive burdens of drug toxicity. However, because many anticancer drugs are designed to simply kill cancer cells, often in a semi-specific fashion, the distribution of anticancer drugs in healthy organs or tissues is especially undesirable due to the potential for severe side effects. Consequently, systemic application of these drugs often causes severe side effects in other tissues (e.g. bone marrow suppression, cardiomyopathy, neurotoxicity), which greatly limits the maximal allowable dose of the drug. In addition, rapid elimination and widespread distribution into non-targeted organs and tissues requires the administration of a drug in large quantities, which is often not economical and sometimes complicated due to non-specific toxicity. This vicious cycle of large doses and the concurrent toxicity is a major limitation of current cancer therapy. In many instances, it has been observed that the patient succumbs to the ill effects of the drug toxicity far earlier than the tumor burden.

This symposium will address the potential ways in which nanotechnology can address these challenges. Distinguished speakers will summarize the current state of the art and future barriers. Contributions are also solicited in the following topics.

• Science and technologies for cancer diagnostic and imaging techniques using nanoparticles as reporter platforms and contrast enhancing agents;
• Bionalaytical nanotechnology for detection of biomarkers
• Nanoparticle platforms polymeric nanoparticles, lipid nanoparticles, metal nanoparticles, magnetic nanoparticles, and self-assembling nanosystems;
• Synthetic chemistry required to design and optimize new strategies for nanoparticle preparation and functionalization;
• Therapeutic targeted and intra-cellular drug and gene delivery using nanocarriers;
• Nanoparticles for delivery of electromagnetic energy for hyperthermia and thermal ablation of tumors;
• Theoretical modeling of nanoparticle processes in biological and medical environments, and of drug and gene delivery;
• Combination therapies (drug and energy delivery) using nanoparticles
• Clinical diagnosis and therapy of prostate, breast, and liver cancer.

Topics & Application Areas

• Cancer Diagnostics
• Cancer Biomarkers
• Cancer Immunotherapeutics
• Cancer Ligands
• Drug Delivery
• Other

 

Sponsor & Exhibitor Opportunities

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Please contact: Denise Lee

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Advanced Materials
Electronics & Microsystems
Medical & Biotech
Energy & Environment
Business & Partnering

 

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Sponsorship Opportunities: Contact Denise Lee

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