Vascular and tumor imaging using targeted viral nanoparticles

Marianne  Manchester

Marianne Manchester

Professor

University of California at San Diego

Dr. Marianne Manchester joined the Skaggs School of Pharmacy and Pharmaceutical Sciences in November 2009. She received her Ph.D. in genetics from the Lineberger Comprehensive Cancer, the University of North Carolina, Chapel Hill in 1992. She completed a postdoctoral fellowship in disease pathogenesis and inflammation at The Scripps Research Institute in La Jolla, CA. Dr. Manchester served as an Assistant and Associate Professor on the faculty of The Scripps Research Institute, Departments of Neuropharmacology and Cell Biology, from 1998- 2009.

Dr. Manchester specializes in novel virus-based nanotechnologies for tumor targeting and vaccine development. She has developed tissue-directed nanoparticles that show specificity for tumors in vivo, and was the first to demonstrate the utility of viral nanoparticles as a tool for intravital vascular imaging. She has been instrumental in developing virus-based structural scaffolds for antigen presentation that demonstrate the positive effects of whole antigen display and antigen multivalency on protective immunity. She leads NIH-sponsored programs in tumor nanotechnology, and multivalent nanotechnologies for vaccine development. She has also developed novel mass spectrometry-based approaches for identifying new therapeutic targets for human disease. She has authored more than 70 peer-reviewed scientific publications and is an inventor on 4 patents or patents pending.

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