NSTI BioNano 2010

Digital signal processing post-hybridization of DNA Biosensor

S.A. Afuwape
NATIONAL UNIVERSITY, US

Keywords: non-label DNA biosensor, field-effect transistors, discrete transfer functions, power spectral density, coding region, DSP applications

Abstract:

The non-label DNA biosensor detects hybridization due to enhanced biomolecules surface-binding specifically on glass or plastic platform, now broadly extended to active surface such as field-effect transistors with scalability of the platform gate. The latter platform provides opportunity to compute the transfer functions of the activities on the functionalized surface pre and post DNA hybridization. In this paper, the discrete transfer functions are derived and exploited to compute and display the codon regions while the computed Fourier response provided the power spectral density at 2π/3 frequency domain. The DNA sequences are digitally filtered to narrow bandpass center at the coding region. Furthermore digital signal processing DSP applications are propounded for exploration into customized pharmaceutical, medical, environmental, agriculture, and defense, based on oligonucleotide DNA hybridization.
 
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