NSTI BioNano 2010

An Intracranial Neurocompatible Nanocomposite Polymeric Device for the Chronic Management of AIDS Dementia Complex

R.A. Khan, S-L. Harilall, V. Pillay, Y.E. Choonara, L.C. du Toit, G. Modi, D. Naidoo, S. Iyuke
Integral University, IN

Keywords: polymeric nano composite, intracranial delivery, neurocompatible, AIDS dementia complex


This study focused on the design, biometric simulation and development of a biodegradable Composite Intracranial Nano-enabled Device (CIND) for the intracranial delivery of zidovudine (AZT) in the treatment of AIDS Dementia Complex (ADC), a common CNS complication of late HIV-1 infection. AZT monotherapy administered orally is the gold standard in managing ADC but has limited bioavailability and significant side-effects. Due to the restrictive Blood-Brain Barrier nanoparticles can be used to penetrate the BBB and provide intracranial drug delivery. The CIND was modulated through biometric simulation and computational prototyping to produce a stable ternary crosslinked scaffold fixated with AZT-loaded alginate (ALG) nanoparticles.
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