NSTI BioNano 2010

Chitosan Membrane in Combinations with Nanoparticles and Adriamycin as a Treatment to Inhibit Glioma Growth and Migration

S.W. Leung, W. Gao, H. Gu, A. Bhushan, J.C.K. Lai
Idaho State University, US

Keywords: chitosan, nanoparticles, adriamycin, cancer therapy, U87 cells

Abstract:

Our previous and on-going studies indicated that U87 cells cultured on chitosan film/membrane exhibited significantly slower growth and proliferation kinetics compared to U87 cells cultured in the absence of chitosan film/membrane. Chitosan exhibits anti-microbial activities through its interaction(s) with microbial cell surface thereby altering their gene expression and cellular function and leading to cell death. Recent studies of nanometal particles have revealed many properties that were not previously expected in biological systems and thus can be explored for various applications in biomedical applications. In this study, we hypothesized that the inhibitory effect of chitosan would be greatly modulated if we combine chitosan with nanometals and adriamycin, a common drug for cancer therapy. Our results showed that combinations of metal nanoparticles, adriamycin and chitosan induced cell death at different rates, with reference to U87 cells cultured in the absence of chitosan and with chitosan alone. The results showed potentials for pathophysiological applications to inhibit human brain glioma migration and invasion. Results of similar treatments with different cancer and normal cells will also be presented.
 
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