NSTI BioNano 2010

How to define the chemical functionalization of materials to construct competitive silicon based nanobiosensors?

M.-J. Bañuls, S. Peransí, V. Toccafondo, J. García-Rupérez, R. Puchades, Á. Maquieira
Universidad Politécnica de Valencia., ES

Keywords: surface chemical functionalizaton, silicon based materials, selective functionalization

Abstract:

In the chemical modification of surface materials to develop nanobiosensors, apart of the general requirements of high surface coverage yield, robustness of the attachment, and biocompatibility of the conditions; many times the selective attachment of the probes only on the sensing areas of the full device is especially encouraged to achieve the maximum performances. We have developed our work searching for surface modification approaches allowing, when necessary, this desired selectivity on two different silicon based materials-silicon nitride, silicon oxide and silicon used to construct nanosensing structures. Finally, the developed chemistries have been applied for the optical biosensing of model systems, using nanophotonic devices reaching good spatial resolutions and sensitivities of 16 pg/mm2 and of 22.2 nM for BSA and dsDNA, respectively.
 
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