NSTI BioNano 2010

Nanoporous Membranes for Medical Applications

R.J. Narayan
University of North Carolina and North Carolina State University, US

Keywords: nanoporous materials, pulsed laser deposition, biosensors

Abstract:

Biofouling plays a major role in instability of implanted biosensors. Biosensor membrane materials must exhibit limited protein adsorption in order to enable biosensor function for extended periods of time. Furthermore, biosensor membranes must exhibit low thicknesses and high porosities in order to allow the biosensors to respond to fluctuations in analyte levels. In this study, the use of physical vapor deposition technologies such as pulsed laser deposition to prepare coatings on nanoporous alumina membranes for biosensor applications is discussed. The modified nanoporous alumina membranes were examined using several techniques, including scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, and platelet rich plasma testing. We anticipate that these novel materials could find use in biosensors as well as kidney dialysis membranes, drug delivery devices, and other devices facing biocompatibility issues that limit function.
 
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