NSTI BioNano 2010

A “leukolike” multistage delivery system to overcome biological barriers

N. Qauttrocchi, C. Chiappini, L. Cooper, M. Ferrari, E. Tasciotti
University of Texas Health Science Center, US

Keywords: delivery system, nanoporous silicon particles

Abstract:

Delivery systems based on Nanoporous Silicon Particles (NSPs) have been proposed as ideal candidates for the targeted release of drug and contrast agents to tumor sites as porous silicon is biocompatible, biodegradable and easy to functionalize. However due to limitations with their structure and surface properties, NSPs are still unable to overcome the multiplicity of biological barriers they encounter after intravenous administration and that adversely impact their ability to reach the intended target at effective concentrations. We propose a “leukolike” system composed of NSPs, preloaded with diagnostic and therapeutic nanoparticles and coated with the cellular membranes of primary leukocytes isolated from the peripheral blood of mice. This new delivery system might be able to: i) avoid sequestration by the reticulo-endothelial system (RES); ii) increase the transcytosis through the endothelial barrier; iii) reduce the response of the immune system against the injected components; and iv) target the lesion site by taking advantage of the physiological mechanisms that allow leukocytes to freely circulate in the blood stream and to reach the tumor site.
 
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