NSTI BioNano 2010

Doxorubicin-loaded and Antibody-Conjugated Liposome-QD Hybrid Vesicles for Targeted Cancer Therapy and Imaging

B.W. Tian, W.T. Al-Jamal, M. Stuartb, K. Kostarelos
The School of Pharmacy, University of London, UK

Keywords: multimodal vesicles, targeted cancer therapy, imaging, MUC1

Abstract:

In this study, we report the engineering of multimodal Liposome-QD hybrids (L-QD) for cancer imaging and therapy. L-QD hybrids were loaded with doxorubicin (Dox) using the osmotic gradient technique, achieving high encapsulation efficiency comparable to liposome alone. Structural elucidation using cryogenic electron microscopy (cryo-EM) clearly showed that QD were incorporated in the lipid bilayer and Dox crystals were encapsulated into the liposome aqueous core. Furthermore, the surface of Dox-loaded hybrids were functionalized with anti-MUC-1 antibody for active targeting, using the post-insertion technique.MUC-1 antibody-targeted L-QD hybrids encapsulating doxorubicin are thought to constitute a potential multimodal system for the simultaneous delivery of therapeutic and diagnostic agents to cancer cells in vitro and in vivo.
 
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