NSTI BioNano 2010

Nonlabelled Nanocarbon for application of targeting Tumor Cells Causing Thermal Energy Ablation Using Short Cycle Microwave Energy as Primary Or Adjunctive Therapy

M. DeSantis, T. Dalessandro, J. Ferretti, R. Mashioff, W. Bowne, S. Sclafani, J. Sorrento
VA MED CTR, US

Keywords: nanocarbon cancer therapy magnetic

Abstract:

Methods : Non-Nanotube Nanocarbon-sphere Sp2 chains (coronene) production is accomplished by introducing a hydrocarbon into a molten alloy bath, resulting in a chemical reduction followed by a remediation of the molecular structures into carbon nano material. This nanocarbon was evaluated using short cycle microwave energy using tissue equivalent human. Radiologic imaging and MRI imaging was performed. Results : Nanocarbon core aromatic molecules have strong electromagnetic ring currents in the aromatic sextants with the strongest EM currents in the central hexabenzo-coronenide complex. Addition of 0.333grams of Coronene Ion nanocarbon to 100ml of water(a 0.2275 molar solution) improved energy transfer to heat by 51% over non treated water. Our work demonstrated that using a small amount of energy in the microwave spectrum, can cause a similar pathologic effect on tumor cells equivalent to high energy ionizing radiation. Due to its inherent magnetic properties, steerage to tumor cells by high gauss magnetic fields is possible. Conclusions : This new nanocarbon has high absorbance of microwave energy which is rapidly converted with high effect to thermal energy invitro. Utilizing radiolabelling to assist in imaging, this nanocarbon candidate would aid in energy targeting causing thermal ablation of tumors while significantly reducing thermal energy to non treated tissue.
 
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