NSTI BioNano 2010

Computational Modeling of Electromagnetically Induced Heating of Magnetic Nanoparticle Materials for Hyperthermic Cancer Treatment

L. Rast, J.G. Harrison
University of Alabama at Birmingham, US

Keywords: hyperthermia, cancer, nanotechnology, modeling, ferrofluid, magnetic nanoparticles, computational, finite difference time domain


We present results on the computational modeling of electromagnetically induced heating for the purpose of hyperthermic cancer treatment with magnetic nanoparticle fluids. Magnetic hyperthermia can therefore be used for direct targeting and destruction of tumors through heat treatment or as a compliment to chemotherapy. magnetic nanoparticle fluid hyperthermia for cancer treatment requires that appreciable volumetric heating power be generated, while maintaining safe values of frequency and magnetic field strength and reducing the risk of spot heating healthy tissue. It is therefore necessary to determine an ideal range of input parameters for the complex magnetic susceptibility of the ferrofluid, as well as the magnitude of the driving magnetic field. We do this by the coupling of the solution of Maxwell’s equations in a model of the tumor and surrounding tissue as input to the solution to the Pennes’ Bioheat Equation (PBE). Both sets of equations are solved via the Finite Difference Time Domain Method.
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