NSTI BioNano 2010

Electrochemical Mechanics of Nanometer-Scaled Structural Layers of Bacterial Spores

S.V. Kazakov
Pace University, US

Keywords: spores, nanolayers, structure, transformation, ion-sensitivity, model


The early events in the nutrient and non-nutrient germination of Bacillus subtilis spores are considered in combination with the properties of nanometer-scaled spore structural layers. All structural, not metabolically mediated, transformations at the early steps of germination (cortex contraction/swelling, inner membrane ionic permeability, core water uptake, Ca-DPA release, and activation of cortex degradation) are incorporated into a unique model termed as electrochemical mechanics of bacterial spores. The model is based on the common feature fastening the events involved: they are ion-sensitive. We believe that new sensory mechanisms and pathways of metabolic dormancy control uncovered in this work can be applied in biosensors for the purposes of biomedicine and biotechnology (new generation of nanobioanalytical systems). The proposed model of electrochemical mechanics of bacterial spores can be a basis for development of protocols for disinfection, sterilization, preservation, and therapeutic treatments, as well as for discrimination among species of Bacillus genus (spore detection and identification, biodefense).
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