NSTI BioNano 2010

Bimolecules in multimodal and multifunctional bioimaging database: potentials and applications

R. Sharma, A. Sharma
Innovations And Solutions, Inc., US

Keywords: proteins, oligonucleotides, MRI-PET, multimodal imaging, gene expression

Abstract:

Oligonucleotides are biomarkers in gene expression imaging and proteins for imaging proteomics based on these end product molecules as visible by MRI and PET to give structural and metabolic information in diseased tissue. We compiled the database based on oligonucleotides and proteins, their biochemical electrophoretic properties and matched measurable imaging signal properties (relaxation constants for MRI; SUV for PET; and OD for bioluminescence) generated by different proteins and oligonucleotides available for bioimaging of tumors. The novelty of using database is the unique selection of molecule(s) as biosensor or reporter with its specific sensitivity to the imaging modality to translate the mechanistic chemical details on digitized maps (image) from tissue in non-invasive manner. The database has utility in developing new modalities of tumor diagnostic imaging.
 
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